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KMID : 0616620020080010075
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Journal of Soonchunhyang Medical College
2002 Volume.8 No. 1 p.75 ~ p.82
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Apoptosis index, Ki-67 proliferation index, and p53 protein expression in Helicobacter pylori gastritis associated with gastric adenoma and early gastric cancer
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Jin So-Young
Lee Dong-Wha
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Abstract
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Helicobacter pylori(H. pylori) is the main cause of chronic gastritis, which may progress to cancer through atrophy, metaplasia, and dysplasia. To investigate the relationship between H. pylori and gastric precancerous and cancerous lesions, we examined a total of 55 cases of H.pylori gastritis associated with 30 gastric adenomas and 25 early gastric cancers. Apoptosis index, Ki-67 proliferation index, and p53 protein expression were counted after TUNEL and immunohistochemistry. Apoptosis indices of each group were statistically not significantly different Ki-67 proliferation index was highest in adenoma group (15.1±8.3) and lowest in submucosal carinoma group (7.8±8.3)(p<0.05). Overall p53 protein expression rate was 49.1%. The pattern of p53 protein expression was scattered in adenoma group(5/6) whereas more grouped in higher grade lesion group. According to the above findings, relative decrement of apoptosis and grouped pattern of p53 protein expression in H. pylori gastritis associated with higher grade lesion might be related with progression of H. pylori gastritis to the precancerous and cancerous lesions.
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KEYWORD
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Helicobacter pylori gastritis, gastric adenoma, early gastric cancer, Ki-67 proliferation index, apoptosis index, p53 protein
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